I have not used I2C ports yet. However, I have a little bug with permanent light up RX and TX LEDs. If you mean an arrangement of the A B C buttons, so this arrangement was more suitable for me.
Yes, it's a little thicker, but it's because the battery is 8.3mm thick. If the battery was a little bit thicker, I would have to a little deepen the bottom cover. The current thickness of my clone (fully assembled) is 23.75mm.
Sorry for my English.